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Pardee, Timothy
One or more keywords matched the following items that are connected to Pardee, Timothy
Item TypeName
Academic Article Mouse models of human AML accurately predict chemotherapy response.
Academic Article Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
Academic Article Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction.
Concept Antineoplastic Agents
Academic Article The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML).
Academic Article A phase I study of the first-in-class antimitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies.
Academic Article The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML.
Academic Article Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway.
Academic Article Improving nucleoside analogs via lipid conjugation: Is fatter any better?
Academic Article The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence.
Academic Article A Phase II Clinical Trial of CPI-613 in Patients with Relapsed or Refractory Small Cell Lung Carcinoma.
Academic Article The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia.
Academic Article Mitochondria in cancer metabolism, an organelle whose time has come?
Academic Article Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.
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  • Antineoplastic Agents